Biomarker Targets for Longevity
Standard reference ranges are designed to detect acute pathology. Optimization requires targeting the percentiles associated with the lowest all-cause mortality. We break down the evidence for aggressive targets.
Cardiovascular (Lipid & Endothelial)
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ApoB (Apolipoprotein B)
The primary driver of atherosclerosis. Why LDL-C is an incomplete metric and the case for targeting ApoB < 60 mg/dL.
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Lp(a) (Lipoprotein(a))
The genetic risk factor present in ~20% of the population. Testing protocols and emerging therapeutics.
Metabolic & Glycemic
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Fasting Insulin & HOMA-IR
Detecting insulin resistance years before HbA1c elevation. The argument for targeting Fasting Insulin < 5 μIU/mL.
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Uric Acid
Beyond gout: Uric acid as a marker of fructose metabolism and metabolic syndrome risk.