Fisetin: The Mayo Clinic Protocol
Senolytics target senescent cells—cells that have stopped dividing but resist apoptosis, secreting inflammatory cytokines (SASP). Fisetin, a flavonoid, is currently undergoing clinical trials (e.g., NCT03675724 at the Mayo Clinic, initiated in 2018) for its senolytic properties.
The Protocol
Unlike daily vitamins, senolytics are dosed in a "hit and run" manner to kill senescent cells and then allow the body to clear them.
- Dose: ~20mg/kg of body weight.
- Frequency: Taken for 2-3 consecutive days, then paused for 28-30 days.
Worked Example: Fisetin Dosing
For a 75kg individual: 75kg × 20mg/kg = 1500mg per day for 2 days.
Common Mistakes
- Daily Dosing: Taking fisetin daily at lower doses (e.g., 100mg) acts primarily as an antioxidant, not a senolytic.
- Poor Absorption: Fisetin is highly lipophilic. Taking it without a fat source drastically reduces bioavailability.
Frequently Asked Questions
- Is this FDA approved?
- No. Fisetin is a dietary supplement, and senolytic therapy is experimental in humans.
- What about Quercetin?
- Quercetin is often paired with Dasatinib (a chemotherapy drug) in other senolytic protocols, but Fisetin is typically studied as a monotherapy for this specific mechanism.